77. Combinatorial Self-Assembly of Glycan Fragments into Microarrays
    K.-T. Huang, K. Gorska, S. Alvarez, S. Barluenga, N. Winssinger
    ChemBioChem 2011, 12, 56-60

Complex glycan arrays: A general method for preparing thioglycosides from native oligosaccharides and coupling them to peptide nucleic acids (PNAs) is reported. An array of 625 glycans was assembled by hybridization of two PNA-encoded libraries of 25 glycan fragments. The cooperativity of the fragment for carbohydrate binding proteins was validated with lectins of known specificity.

DOI: 10.1002/cbic.201000567 

open archive unige:24696